Everything about Tioguanine totally explained
Tioguanine (
INN), formerly
Thioguanine (
BAN), is a
drug that's used in the treatment of
cancer. It belongs to the family of drugs called
antimetabolites. It is a
guanine analog. Its principal use is in
acute leukaemias and
chronic myeloid leukaemia.
Pharmacology
As a guanine analogue, it's transformed inside the cell into to 6-thioguanilyic acid (TGMP), which, by pseudofeedback interference with purine biosynthesis, interferes with the synthesis of guanine nucleotides. Some of its activity may also be due to the incorporation of thioguanine nucleotides into both
RNA and
DNA, but the end-result is inducing
cell cycle arrest and
apoptosis. It is metabolized via methylation by
thiopurine methyltransferase.
Further Information
Get more info on 'Tioguanine'.
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